In this work, we cast the X3DH protocol as a specific type of authenticated key exchange (AKE) protocol, which we call a mph{Signal-conforming AKE} protocol, and formally define its security model based on the vast prior work on AKE protocols. We then provide the first efficient generic construction of a Signal-conforming AKE protocol based on standard cryptographic primitives such as key encapsulation mechanisms (KEM) and signature schemes, all of which are known to be instantiable from standard assumptions. Specifically, this results in the first post-quantum secure replacement of the X3DH protocol on well-established assumptions.Similarly to the X3DH protocol, our Signal-conforming AKE protocol offers a strong (or stronger) flavor of security, where the exchanged key remains secure even when all the non-trivial combinations of the long-term secrets and session-specific secrets are compromised. Moreover, our protocol has a weak flavor of deniability and we further show how to strengthen it using ring signatures. Finally, we provide a full-fledged, generic C implementation of our (weakly deniable) protocol. We instantiate it with several Round 3 candidates (finalists and alternates) to the NIST post-quantum standardization process and compare the resulting bandwidth and computation performances. Our implementation is available with this submission.